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glabrata is known to present a low susceptibility to azoles (Arendrup et al., 2013) and a significant resistance to amphotericin B (Pappas et al., 2016), which was proposed to be associated with the presence of fungal cell wall transporters and their increased activity in the export of antifungal agents (Cavalheiro et al., 2021)

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Therefore, vitamin B12 deficiency leads to homocysteine accumulation, impaired DNA synthesis, and hematologic abnormalities such as formation of hypersegmented neutrophils and megaloblastic anemia, a condition in which the bone marrow produces unusually large, structurally abnormal and immature red blood cells called megaloblasts as a consequence of ineffective hematopoiesis[4]